diff --git a/scripts/faspr.py b/scripts/faspr.py
new file mode 100644
index 0000000..981cba2
--- /dev/null
+++ b/scripts/faspr.py
@@ -0,0 +1,113 @@
+"""
+Wrapper to run FASPR side chain packing on a pdb file.
+
+https://github.com/tommyhuangthu/FASPR
+"""
+
+import os
+import argparse
+from glob import glob
+from collections import defaultdict
+import itertools
+import tempfile
+import subprocess
+import shlex
+import logging
+import multiprocessing as mp
+from typing import *
+
+from foldingdiff.tmalign import match_files
+
+
+logging.basicConfig(level=logging.INFO)
+FASPR_BIN = os.path.expanduser("~/software/FASPR/FASPR")
+assert os.path.isfile(FASPR_BIN)
+
+
+def read_fasta(fasta_fname: str) -> Dict[str, str]:
+    """Read the fasta file as a dict mapping identifiers to sequences."""
+    retval = defaultdict(str)
+    with open(fasta_fname, "r") as f:
+        for line in f:
+            line = line.strip()
+            if line.startswith(">"):
+                identifier = line[1:]
+            else:
+                retval[identifier] += line
+    return retval
+
+
+def run_faspr(input_pdb: str, input_fasta: str, output_pdb: str) -> str:
+    """Run FASPR and write structure to output_pdb."""
+    # sequence should be written a single line of one-letter alphabet; we read
+    # in the fasta file and rewrite the sequences to adhere to this format
+    fasta_seqs = read_fasta(input_fasta)
+    assert len(fasta_seqs) == 1
+
+    with tempfile.TemporaryDirectory() as tmpdir:
+        # Write the fasta file
+        seq_fname = os.path.join(tmpdir, "seq.txt")
+        with open(seq_fname, "w") as sink:
+            sink.write(fasta_seqs.popitem()[1] + "\n")
+
+        # Run FASPR
+        cmd = f"{FASPR_BIN} -i {input_pdb} -s {seq_fname} -o {output_pdb}"
+        subprocess.check_call(
+            shlex.split(cmd), stderr=subprocess.DEVNULL, stdout=subprocess.DEVNULL
+        )
+    return output_pdb
+
+
+def build_parser() -> argparse.ArgumentParser:
+    """Build a basic CLI parser."""
+    parser = argparse.ArgumentParser(
+        usage="Wrapper for running FASPR",
+        formatter_class=argparse.ArgumentDefaultsHelpFormatter,
+    )
+    parser.add_argument(
+        "input_pdb_dir", type=str, help="Input dir containing .pdb files"
+    )
+    parser.add_argument(
+        "input_fasta_dir", type=str, help="Input dir containing .fasta files"
+    )
+    parser.add_argument("output_pdb_dir", type=str, help="Output dir for .pdb files")
+    return parser
+
+
+def main():
+    """Run script."""
+    args = build_parser().parse_args()
+
+    query2fasta = match_files(
+        glob(os.path.join(args.input_pdb_dir, "*.pdb")),
+        glob(os.path.join(args.input_fasta_dir, "*.fasta")),
+        strategy="prefix",
+    )
+    logging.info(
+        f"Matched {len(query2fasta)} pdb files to {len(list(itertools.chain.from_iterable(query2fasta.values())))} fasta files"
+    )
+
+    # Make the output directory
+    os.makedirs(args.output_pdb_dir, exist_ok=True)
+
+    # Create arg tuples (pdb, fasta, out_pdb)
+    arg_tuples = []
+    for query_pdb, fasta_files in query2fasta.items():
+        for fasta_file in fasta_files:
+            arg_tuples.append(
+                (
+                    query_pdb,
+                    fasta_file,
+                    os.path.join(
+                        args.output_pdb_dir,
+                        os.path.basename(fasta_file).replace(".fasta", ".pdb"),
+                    ),
+                )
+            )
+
+    with mp.Pool(mp.cpu_count()) as pool:
+        pool.starmap(run_faspr, arg_tuples, chunksize=10)
+
+
+if __name__ == "__main__":
+    main()