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foundry/_sources/models/mpnn/index.md.txt
2026-06-03 21:14:08 +00:00

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# MPNN Documentation
```{warning}
The documentation for the MPNN model is currently incomplete.
If you would like to contribute, feel free to open a PR.
```
```{warning}
The MPNN model is still being benchmarked for comparison to the
original ProteinMPNN, LigandMPNN, and SolubleMPNN implementations.
```
The MPNN model in [foundry](https://github.com/RosettaCommons/foundry)
has all of the functionality of [ProteinMPNN](https://www.science.org/doi/10.1126/science.add2187),
[LigandMPNN](https://www.nature.com/articles/s41592-025-02626-1),
and [SolubleMPNN](https://www.nature.com/articles/s41586-024-07601-y),
but with the backend support of [atomworks](https://github.com/RosettaCommons/atomworks) and
[foundry](https://github.com/RosettaCommons/foundry). More MPNN
models and weights will be added to foundry in the future.
Are we missing a model you would like to work with? Create a PR with the
necessary files and/or code changes or open an issue requesting it.