diff --git a/Code/GraphMol/FileParsers/MolFileParser.cpp b/Code/GraphMol/FileParsers/MolFileParser.cpp
index 208035f96..e58aa779b 100644
--- a/Code/GraphMol/FileParsers/MolFileParser.cpp
+++ b/Code/GraphMol/FileParsers/MolFileParser.cpp
@@ -151,6 +151,17 @@ std::string getV3000Line(std::istream *inStream, unsigned int &line) {
   ++line;
   auto inl = getLine(inStream);
   std::string_view tempStr = inl;
+
+  // Reject any non-ascii characters.
+  if (std::any_of(tempStr.begin(), tempStr.end(), [](char c) {
+    return static_cast<unsigned char>(c) > 127;
+    })) {
+    std::ostringstream errout;
+    errout << "Invalid character found in data stream when parsing V3000 line: "
+           << tempStr;
+    throw MolFileUnhandledFeatureException(errout.str());
+  }
+  
   if (tempStr.size() < 7 || tempStr.substr(0, 7) != "M  V30 ") {
     std::ostringstream errout;
     errout << "Line " << line << " does not start with 'M  V30 '" << std::endl;
diff --git a/Code/GraphMol/FileParsers/MolSGroupParsing.cpp b/Code/GraphMol/FileParsers/MolSGroupParsing.cpp
index f02366f22..330387b45 100644
--- a/Code/GraphMol/FileParsers/MolSGroupParsing.cpp
+++ b/Code/GraphMol/FileParsers/MolSGroupParsing.cpp
@@ -1132,7 +1132,17 @@ void ParseV3000ParseLabel(const std::string &label,
     } else if (label == "PARENT") {
       // Store relationship until all SGroups have been read
       unsigned int parentIdx;
+      if (lineStream.eof()) {
+        std::ostringstream errout;
+        errout << "PARENT label not found on line " << line;
+        throw FileParseException(errout.str());
+      }
       lineStream >> parentIdx;
+      if (lineStream.fail()) {
+        std::ostringstream errout;
+        errout << "Invalid PARENT label found on line " << line;
+        throw FileParseException(errout.str());
+      }
       sgroup.setProp<unsigned int>("PARENT", parentIdx);
     } else if (label == "COMPNO") {
       unsigned int compno;
diff --git a/Code/GraphMol/SmilesParse/CXSmilesOps.cpp b/Code/GraphMol/SmilesParse/CXSmilesOps.cpp
index ee58181a9..e7ef6f6d9 100644
--- a/Code/GraphMol/SmilesParse/CXSmilesOps.cpp
+++ b/Code/GraphMol/SmilesParse/CXSmilesOps.cpp
@@ -736,6 +736,10 @@ bool parse_data_sgroup(Iterator &first, Iterator last, RDKit::RWMol &mol,
   }
   ++first;
 
+  if (first >= last) {
+    return false;
+  }
+  
   parse_data_sgroup_attr(first, last, sgroup, keepSGroup, "FIELDNAME");
 
   // FIX:
@@ -743,12 +747,24 @@ bool parse_data_sgroup(Iterator &first, Iterator last, RDKit::RWMol &mol,
     sgroup.setProp("FIELDDISP", "    0.0000    0.0000    DR    ALL  0       0");
   }
 
+  if (first >= last) {
+    return false;
+  }
   parse_data_sgroup_attr(first, last, sgroup, keepSGroup, "DATAFIELDS", true);
 
+  if (first >= last) {
+    return false;
+  }
   parse_data_sgroup_attr(first, last, sgroup, keepSGroup, "QUERYOP");
 
+  if (first >= last) {
+    return false;
+  }
   parse_data_sgroup_attr(first, last, sgroup, keepSGroup, "FIELDINFO");
 
+  if (first >= last) {
+    return false;
+  }
   parse_data_sgroup_attr(first, last, sgroup, keepSGroup, "FIELDTAG");
 
   if (first < last && *first == '(') {