diff --git a/Code/GraphMol/MolPickler.h b/Code/GraphMol/MolPickler.h
index 1187397ff..c5e5fac7f 100644
--- a/Code/GraphMol/MolPickler.h
+++ b/Code/GraphMol/MolPickler.h
@@ -30,6 +30,7 @@
 #include <ios>
 #endif
 #include <cstdint>
+#include <RDGeneral/BetterEnums.h>
 
 namespace RDKit {
 class ROMol;
@@ -48,20 +49,19 @@ class RDKIT_GRAPHMOL_EXPORT MolPicklerException : public std::exception {
 };
 
 namespace PicklerOps {
-typedef enum {
-  NoProps = 0,  // no data pickled (default pickling, single-precision coords)
-  MolProps = 0x1,  // only public non computed properties
-  AtomProps = 0x2,
-  BondProps = 0x4,
-  QueryAtomData =
-      0x2,  // n.b. DEPRECATED and set to AtomProps (does the same work)
-  PrivateProps = 0x10,
-  ComputedProps = 0x20,
-  AllProps = 0x0000FFFF,        // all data pickled
-  CoordsAsDouble = 0x00010000,  // save coordinates in double precision
-  NoConformers =
-      0x00020000  // do not include conformers or associated properties
-} PropertyPickleOptions;
+BETTER_ENUM(
+    PropertyPickleOptions, unsigned int,
+    NoProps = 0,  // no data pickled (default pickling, single-precision coords)
+    MolProps = 0x1,  // only public non computed properties
+    AtomProps = 0x2, BondProps = 0x4,
+    QueryAtomData =
+        0x2,  // n.b. DEPRECATED and set to AtomProps (does the same work)
+    PrivateProps = 0x10, ComputedProps = 0x20,
+    AllProps = 0x0000FFFF,        // all data pickled
+    CoordsAsDouble = 0x00010000,  // save coordinates in double precision
+    NoConformers =
+        0x00020000  // do not include conformers or associated properties
+);
 }  // namespace PicklerOps
 
 //! handles pickling (serializing) molecules
@@ -188,10 +188,12 @@ class RDKIT_GRAPHMOL_EXPORT MolPickler {
     MolPickler::molFromPickle(pickle, &mol, propertyFlags);
   }
   static void molFromPickle(const std::string &pickle, ROMol *mol) {
-    MolPickler::molFromPickle(pickle, mol, PicklerOps::AllProps);
+    MolPickler::molFromPickle(pickle, mol,
+                              PicklerOps::PropertyPickleOptions::AllProps);
   }
   static void molFromPickle(const std::string &pickle, ROMol &mol) {
-    MolPickler::molFromPickle(pickle, &mol, PicklerOps::AllProps);
+    MolPickler::molFromPickle(pickle, &mol,
+                              PicklerOps::PropertyPickleOptions::AllProps);
   }
 
   //! constructs a molecule from a pickle stored in a stream
@@ -202,10 +204,12 @@ class RDKIT_GRAPHMOL_EXPORT MolPickler {
     MolPickler::molFromPickle(ss, &mol, propertyFlags);
   }
   static void molFromPickle(std::istream &ss, ROMol *mol) {
-    MolPickler::molFromPickle(ss, mol, PicklerOps::AllProps);
+    MolPickler::molFromPickle(ss, mol,
+                              PicklerOps::PropertyPickleOptions::AllProps);
   }
   static void molFromPickle(std::istream &ss, ROMol &mol) {
-    MolPickler::molFromPickle(ss, &mol, PicklerOps::AllProps);
+    MolPickler::molFromPickle(ss, &mol,
+                              PicklerOps::PropertyPickleOptions::AllProps);
   }
 
  private:
diff --git a/Code/JavaWrappers/ROMol.i b/Code/JavaWrappers/ROMol.i
index 46a7cc482..99ae4f140 100644
--- a/Code/JavaWrappers/ROMol.i
+++ b/Code/JavaWrappers/ROMol.i
@@ -192,6 +192,7 @@
 %include "enums.swg"
 %javaconst(1);
 #endif
+%include <RDGeneral/BetterEnums.h>
 %include <GraphMol/MolPickler.h>
 #ifdef SWIGJAVA
 %javaconst(0);
diff --git a/Code/MinimalLib/CMakeLists.txt b/Code/MinimalLib/CMakeLists.txt
index 21fffecf7..05a0d82a0 100644
--- a/Code/MinimalLib/CMakeLists.txt
+++ b/Code/MinimalLib/CMakeLists.txt
@@ -34,7 +34,7 @@ if(RDK_BUILD_MINIMAL_LIB)
             set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} ${USE_FLAGS}")
         endif()
     endif()
-    add_executable(RDKit_minimal jswrapper.cpp minilib.cpp)
+    add_executable(RDKit_minimal jswrapper.cpp minilib.cpp JSONParsers.cpp)
     target_link_libraries(RDKit_minimal ${MINIMAL_LIB_LIBRARIES})
 
     set_target_properties(RDKit_minimal PROPERTIES LINK_FLAGS "--bind")
@@ -67,7 +67,7 @@ if(RDK_BUILD_CFFI_LIB)
         set(LIBS_TO_USE ${tmpLibs})
     endif()
     
-    add_library(rdkitcffi SHARED cffiwrapper.cpp)
+    add_library(rdkitcffi SHARED cffiwrapper.cpp JSONParsers.cpp)
     target_link_libraries(rdkitcffi PUBLIC rdkit_base)
     target_link_libraries(rdkitcffi PUBLIC ${LIBS_TO_USE})
     INSTALL(TARGETS rdkitcffi EXPORT rdkit-targets
diff --git a/Code/MinimalLib/JSONParsers.cpp b/Code/MinimalLib/JSONParsers.cpp
new file mode 100644
index 000000000..667872eb3
--- /dev/null
+++ b/Code/MinimalLib/JSONParsers.cpp
@@ -0,0 +1,48 @@
+//
+//  Copyright (C) 2024 Novartis Biomedical Research and other RDKit contributors
+//
+//   @@ All Rights Reserved @@
+//  This file is part of the RDKit.
+//  The contents are covered by the terms of the BSD license
+//  which is included in the file license.txt, found at the root
+//  of the RDKit source tree.
+//
+
+#define USE_BETTER_ENUMS
+#include "JSONParsers.h"
+#include <GraphMol/MolPickler.h>
+#include <GraphMol/FileParsers/PNGParser.h>
+#include <GraphMol/SmilesParse/SmilesJSONParsers.h>
+#include <RDGeneral/BoostStartInclude.h>
+#include <boost/property_tree/ptree.hpp>
+#include <boost/property_tree/json_parser.hpp>
+#include <RDGeneral/BoostEndInclude.h>
+
+namespace RDKit {
+namespace MinimalLib {
+
+void updatePropertyPickleOptionsFromJSON(unsigned int &propFlags,
+                                         const char *details_json) {
+  if (details_json && strlen(details_json)) {
+    std::istringstream ss;
+    boost::property_tree::ptree pt;
+    ss.str(details_json);
+    boost::property_tree::read_json(ss, pt);
+    const auto nodeIt = pt.find("propertyFlags");
+    if (nodeIt != pt.not_found()) {
+      auto propertyFlagsFromJson =
+          (+PicklerOps::PropertyPickleOptions::NoProps)._to_integral();
+      for (const auto *key : PicklerOps::PropertyPickleOptions::_names()) {
+        if (nodeIt->second.get(key, false)) {
+          propertyFlagsFromJson |=
+              PicklerOps::PropertyPickleOptions::_from_string(key)
+                  ._to_integral();
+        }
+      }
+      propFlags = propertyFlagsFromJson;
+    }
+  }
+}
+
+}  // end namespace MinimalLib
+}  // end namespace RDKit
diff --git a/Code/MinimalLib/JSONParsers.h b/Code/MinimalLib/JSONParsers.h
new file mode 100644
index 000000000..581ebe09c
--- /dev/null
+++ b/Code/MinimalLib/JSONParsers.h
@@ -0,0 +1,22 @@
+//
+//  Copyright (C) 2024 Novartis Biomedical Research and other RDKit contributors
+//
+//   @@ All Rights Reserved @@
+//  This file is part of the RDKit.
+//  The contents are covered by the terms of the BSD license
+//  which is included in the file license.txt, found at the root
+//  of the RDKit source tree.
+//
+
+#pragma once
+
+#include <GraphMol/FileParsers/PNGParser.h>
+
+namespace RDKit {
+namespace MinimalLib {
+
+void updatePropertyPickleOptionsFromJSON(unsigned int &propFlags,
+                                         const char *details_json);
+
+}  // end namespace MinimalLib
+}  // end namespace RDKit
diff --git a/Code/MinimalLib/cffi_test.c b/Code/MinimalLib/cffi_test.c
index 2948b5b29..9e6c4643a 100644
--- a/Code/MinimalLib/cffi_test.c
+++ b/Code/MinimalLib/cffi_test.c
@@ -2765,6 +2765,75 @@ void test_custom_palette() {
   free(mpkl);
 }
 
+void test_props() {
+  printf("--------------------------\n");
+  printf("  mol props\n");
+  const char *smi = "c1ccccn1";
+  const char *cxsmi_in = "c1ccccn1 |atomProp:0.a.1|";
+  const char *details = "{\"NoProps\":true}";
+  char *mpkl;
+  size_t mpkl_size;
+  char **prop_list;
+  char *prop;
+  char *cxsmi_out;
+  mpkl = get_mol(smi, &mpkl_size, "");
+  assert(mpkl && mpkl_size);
+  prop_list = get_prop_list(mpkl, mpkl_size, 0, 0);
+  assert(prop_list && !prop_list[0]);
+  free(prop_list);
+  set_prop(&mpkl, &mpkl_size, "a", "1", 0);
+  set_prop(&mpkl, &mpkl_size, "b", "2", 0);
+  prop_list = get_prop_list(mpkl, mpkl_size, 0, 0);
+  assert(prop_list && prop_list[0] && prop_list[1] && !prop_list[2]);
+  assert(!strcmp(prop_list[0], "a"));
+  free(prop_list[0]);
+  assert(!strcmp(prop_list[1], "b"));
+  free(prop_list[1]);
+  free(prop_list);
+  assert(has_prop(mpkl, mpkl_size, "a"));
+  assert(has_prop(mpkl, mpkl_size, "b"));
+  assert(!has_prop(mpkl, mpkl_size, "c"));
+  prop = get_prop(mpkl, mpkl_size, "a");
+  assert(prop);
+  assert(!strcmp(prop, "1"));
+  free(prop);
+  prop = get_prop(mpkl, mpkl_size, "b");
+  assert(prop);
+  assert(!strcmp(prop, "2"));
+  free(prop);
+  assert(clear_prop(&mpkl, &mpkl_size, "a"));
+  assert(!clear_prop(&mpkl, &mpkl_size, "c"));
+  prop_list = get_prop_list(mpkl, mpkl_size, 0, 0);
+  assert(prop_list && prop_list[0] && !prop_list[1]);
+  assert(!strcmp(prop_list[0], "b"));
+  free(prop_list[0]);
+  free(prop_list);
+  prop = get_prop(mpkl, mpkl_size, "a");
+  assert(!prop);
+  prop = get_prop(mpkl, mpkl_size, "b");
+  assert(prop);
+  assert(!strcmp(prop, "2"));
+  free(prop);
+  keep_props(&mpkl, &mpkl_size, "{\"propertyFlags\":{\"NoProps\":true}}");
+  prop_list = get_prop_list(mpkl, mpkl_size, 0, 0);
+  assert(prop_list && !prop_list[0]);
+  free(prop_list);
+  prop = get_prop(mpkl, mpkl_size, "b");
+  assert(!prop);
+  free(mpkl);
+  mpkl = get_mol(cxsmi_in, &mpkl_size, "");
+  cxsmi_out = get_cxsmiles(mpkl, mpkl_size, "");
+  assert(!strcmp(cxsmi_out, "c1ccncc1 |atomProp:2.a.1|"));
+  free(cxsmi_out);
+  free(mpkl);
+  mpkl =
+      get_mol(cxsmi_in, &mpkl_size, "{\"propertyFlags\":{\"NoProps\":true}}");
+  cxsmi_out = get_cxsmiles(mpkl, mpkl_size, "");
+  assert(!strcmp(cxsmi_out, "c1ccncc1"));
+  free(cxsmi_out);
+  free(mpkl);
+}
+
 int main() {
   enable_logging();
   char *vers = version();
@@ -2802,5 +2871,6 @@ int main() {
   test_multi_highlights();
   test_bw_palette();
   test_custom_palette();
+  test_props();
   return 0;
 }
diff --git a/Code/MinimalLib/cffiwrapper.cpp b/Code/MinimalLib/cffiwrapper.cpp
index d1762dd9f..f8d28eff5 100644
--- a/Code/MinimalLib/cffiwrapper.cpp
+++ b/Code/MinimalLib/cffiwrapper.cpp
@@ -85,9 +85,10 @@ char *str_to_c(const char *str) {
 }
 }  // namespace
 
-void mol_to_pkl(const ROMol &mol, char **mol_pkl, size_t *mol_pkl_sz) {
-  unsigned int propFlags = PicklerOps::PropertyPickleOptions::AllProps ^
-                           PicklerOps::PropertyPickleOptions::ComputedProps;
+void mol_to_pkl(
+    const ROMol &mol, char **mol_pkl, size_t *mol_pkl_sz,
+    unsigned int propFlags = PicklerOps::PropertyPickleOptions::AllProps ^
+                             PicklerOps::PropertyPickleOptions::ComputedProps) {
   std::string pkl;
   MolPickler::pickleMol(mol, pkl, propFlags);
   free(*mol_pkl);
@@ -269,9 +270,9 @@ extern "C" char *get_mol(const char *input, size_t *pkl_sz,
     *pkl_sz = 0;
     return nullptr;
   }
-  static const unsigned int propFlags =
-      PicklerOps::PropertyPickleOptions::AllProps ^
-      PicklerOps::PropertyPickleOptions::ComputedProps;
+  unsigned int propFlags = PicklerOps::PropertyPickleOptions::AllProps ^
+                           PicklerOps::PropertyPickleOptions::ComputedProps;
+  MinimalLib::updatePropertyPickleOptionsFromJSON(propFlags, details_json);
   std::string pkl;
   MolPickler::pickleMol(*mol, pkl, propFlags);
   return str_to_c(pkl, pkl_sz);
@@ -873,6 +874,77 @@ extern "C" bool clear_log_buffer(void *log_handle) {
   return 0;
 }
 
+extern "C" short has_prop(const char *mol_pkl, size_t mol_pkl_sz,
+                          const char *key) {
+  auto mol = mol_from_pkl(mol_pkl, mol_pkl_sz);
+  return mol.hasProp(key);
+}
+
+extern "C" char **get_prop_list(const char *mol_pkl, size_t mol_pkl_sz,
+                                short includePrivate, short includeComputed) {
+  auto mol = mol_from_pkl(mol_pkl, mol_pkl_sz);
+  auto propList = mol.getPropList(includePrivate, includeComputed);
+  std::string propNames;
+  for (const auto &prop : propList) {
+    propNames += prop + ",";
+  }
+  auto resLen = sizeof(char *) * (propList.size() + 1);
+  char **res = (char **)malloc(resLen);
+  if (!res) {
+    return nullptr;
+  }
+  memset(res, 0, resLen);
+  for (size_t i = 0; i < propList.size(); ++i) {
+    res[i] = strdup(propList.at(i).c_str());
+    if (!res[i]) {
+      while (i--) {
+        free(res[i]);
+      }
+      return nullptr;
+    }
+  }
+  return res;
+}
+
+extern "C" void set_prop(char **mol_pkl, size_t *mol_pkl_sz, const char *key,
+                         const char *val, short computed) {
+  auto mol = mol_from_pkl(*mol_pkl, *mol_pkl_sz);
+  std::string valAsString(val);
+  mol.setProp(key, valAsString, computed);
+  mol_to_pkl(mol, mol_pkl, mol_pkl_sz);
+}
+
+extern "C" char *get_prop(const char *mol_pkl, size_t mol_pkl_sz,
+                          const char *key) {
+  auto mol = mol_from_pkl(mol_pkl, mol_pkl_sz);
+  if (!mol.hasProp(key)) {
+    return nullptr;
+  }
+  std::string val;
+  mol.getProp(key, val);
+  return strdup(val.c_str());
+}
+
+extern "C" short clear_prop(char **mol_pkl, size_t *mol_pkl_sz,
+                            const char *key) {
+  auto mol = mol_from_pkl(*mol_pkl, *mol_pkl_sz);
+  short res = mol.hasProp(key);
+  if (res) {
+    mol.clearProp(key);
+    mol_to_pkl(mol, mol_pkl, mol_pkl_sz);
+  }
+  return res;
+}
+
+extern "C" void keep_props(char **mol_pkl, size_t *mol_pkl_sz,
+                           const char *details_json) {
+  auto mol = mol_from_pkl(*mol_pkl, *mol_pkl_sz);
+  unsigned int propFlags = PicklerOps::PropertyPickleOptions::AllProps ^
+                           PicklerOps::PropertyPickleOptions::ComputedProps;
+  MinimalLib::updatePropertyPickleOptionsFromJSON(propFlags, details_json);
+  mol_to_pkl(mol, mol_pkl, mol_pkl_sz, propFlags);
+}
+
 #if (defined(__GNUC__) || defined(__GNUG__))
 #pragma GCC diagnostic pop
 #endif
diff --git a/Code/MinimalLib/cffiwrapper.h b/Code/MinimalLib/cffiwrapper.h
index 128e1da69..2224f4ec8 100644
--- a/Code/MinimalLib/cffiwrapper.h
+++ b/Code/MinimalLib/cffiwrapper.h
@@ -164,6 +164,23 @@ RDKIT_RDKITCFFI_EXPORT short destroy_log_handle(void **log_handle);
 RDKIT_RDKITCFFI_EXPORT char *get_log_buffer(void *log_handle);
 RDKIT_RDKITCFFI_EXPORT short clear_log_buffer(void *log_handle);
 
+// props
+RDKIT_RDKITCFFI_EXPORT short has_prop(const char *mol_pkl, size_t mol_pkl_sz,
+                                      const char *key);
+RDKIT_RDKITCFFI_EXPORT char **get_prop_list(const char *mol_pkl,
+                                            size_t mol_pkl_sz,
+                                            short includePrivate,
+                                            short includeComputed);
+RDKIT_RDKITCFFI_EXPORT void set_prop(char **mol_pkl, size_t *mol_pkl_sz,
+                                     const char *key, const char *val,
+                                     short computed);
+RDKIT_RDKITCFFI_EXPORT char *get_prop(const char *mol_pkl, size_t mol_pkl_sz,
+                                      const char *key);
+RDKIT_RDKITCFFI_EXPORT short clear_prop(char **mol_pkl, size_t *mol_pkl_sz,
+                                        const char *key);
+RDKIT_RDKITCFFI_EXPORT void keep_props(char **mol_pkl, size_t *mol_pkl_sz,
+                                       const char *details_json);
+
 #ifdef __cplusplus
 }
 #endif
diff --git a/Code/MinimalLib/common.h b/Code/MinimalLib/common.h
index d9ce6ee6d..ef85e87c1 100644
--- a/Code/MinimalLib/common.h
+++ b/Code/MinimalLib/common.h
@@ -54,7 +54,7 @@
 #include <GraphMol/RGroupDecomposition/RGroupUtils.h>
 #include <RDGeneral/RDLog.h>
 #include "common_defs.h"
-
+#include "JSONParsers.h"
 #include <sstream>
 #include <RDGeneral/BoostStartInclude.h>
 #include <boost/property_tree/ptree.hpp>
diff --git a/Code/MinimalLib/jswrapper.cpp b/Code/MinimalLib/jswrapper.cpp
index e34cd49fd..700bf23e1 100644
--- a/Code/MinimalLib/jswrapper.cpp
+++ b/Code/MinimalLib/jswrapper.cpp
@@ -153,7 +153,12 @@ emscripten::val uint_vector_to_uint32array(
   return res;
 }
 
-emscripten::val get_as_uint8array(const JSMolBase &self) {
+emscripten::val get_as_uint8array(const JSMolBase &self,
+                                  const std::string &details) {
+  return binary_string_to_uint8array(self.get_pickle(details));
+}
+
+emscripten::val get_as_uint8array_no_details(const JSMolBase &self) {
   return binary_string_to_uint8array(self.get_pickle());
 }
 
@@ -428,6 +433,7 @@ EMSCRIPTEN_BINDINGS(RDKit_minimal) {
                 select_overload<std::string(const std::string &) const>(
                     &JSMolBase::get_v3Kmolblock))
       .function("get_as_uint8array", &get_as_uint8array)
+      .function("get_as_uint8array", &get_as_uint8array_no_details)
 #ifdef RDK_BUILD_INCHI_SUPPORT
       .function("get_inchi",
                 select_overload<std::string(const std::string &) const>(
diff --git a/Code/MinimalLib/minilib.cpp b/Code/MinimalLib/minilib.cpp
index 177fafecc..469e23c8d 100644
--- a/Code/MinimalLib/minilib.cpp
+++ b/Code/MinimalLib/minilib.cpp
@@ -143,10 +143,11 @@ std::string JSMolBase::get_json() const {
   return MolInterchange::MolToJSONData(get());
 }
 
-std::string JSMolBase::get_pickle() const {
+std::string JSMolBase::get_pickle(const std::string &details) const {
+  unsigned int propFlags = PicklerOps::AllProps ^ PicklerOps::ComputedProps;
+  MinimalLib::updatePropertyPickleOptionsFromJSON(propFlags, details.c_str());
   std::string pickle;
-  MolPickler::pickleMol(get(), pickle,
-                        PicklerOps::AllProps ^ PicklerOps::ComputedProps);
+  MolPickler::pickleMol(get(), pickle, propFlags);
   return pickle;
 }
 
diff --git a/Code/MinimalLib/minilib.h b/Code/MinimalLib/minilib.h
index 42c0ef85f..0a6d90ec3 100644
--- a/Code/MinimalLib/minilib.h
+++ b/Code/MinimalLib/minilib.h
@@ -42,7 +42,8 @@ class JSMolBase {
   std::string get_molblock() const { return get_molblock("{}"); }
   std::string get_v3Kmolblock(const std::string &details) const;
   std::string get_v3Kmolblock() const { return get_v3Kmolblock("{}"); }
-  std::string get_pickle() const;
+  std::string get_pickle(const std::string &details) const;
+  std::string get_pickle() const { return get_pickle(""); };
 #ifdef RDK_BUILD_INCHI_SUPPORT
   std::string get_inchi(const std::string &options) const;
   std::string get_inchi() const { return get_inchi(""); }
diff --git a/Code/MinimalLib/tests/tests.js b/Code/MinimalLib/tests/tests.js
index b6a1220a3..d41bc8d4e 100644
--- a/Code/MinimalLib/tests/tests.js
+++ b/Code/MinimalLib/tests/tests.js
@@ -3402,6 +3402,25 @@ function test_custom_palette() {
     mol.delete();
 }
 
+function test_pickle() {
+    const mol = RDKitModule.get_mol('c1ccccn1');
+    assert(mol);
+    mol.set_prop('a', '1');
+    assert(mol.get_prop('a') === '1');
+    const pklWithProps = mol.get_as_uint8array();
+    assert(pklWithProps);
+    let molFromPkl = RDKitModule.get_mol_from_uint8array(pklWithProps);
+    assert(molFromPkl);
+    assert(molFromPkl.has_prop('a'));
+    assert(molFromPkl.get_prop('a') === '1');
+    molFromPkl.delete();
+    const pklWithoutProps = mol.get_as_uint8array(JSON.stringify({propertyFlags: { NoProps: true } }));
+    molFromPkl = RDKitModule.get_mol_from_uint8array(pklWithoutProps);
+    assert(molFromPkl);
+    assert(!molFromPkl.has_prop('a'));
+    molFromPkl.delete();
+}
+
 initRDKitModule().then(function(instance) {
     var done = {};
     const waitAllTestsFinished = () => {
@@ -3490,6 +3509,7 @@ initRDKitModule().then(function(instance) {
     }
     test_bw_palette();
     test_custom_palette();
+    test_pickle();
 
     waitAllTestsFinished().then(() =>
         console.log("Tests finished successfully")