diff --git a/CMakeLists.txt b/CMakeLists.txt
index 579e95461..61dbd438b 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -120,7 +120,7 @@ set(RDK_PYTHON_OUTPUT_DIRECTORY "${CMAKE_CURRENT_BINARY_DIR}/rdkit")
 # Config variables:
 set(RDKit_Year "2021")
 set(RDKit_Month "03")
-set(RDKit_Revision "4")
+set(RDKit_Revision "5")
 set(RDKit_RevisionModifier "")
 set(RDKit_ABI "1")
 
diff --git a/ReleaseNotes.md b/ReleaseNotes.md
index 0703dc2b3..6ed48c958 100644
--- a/ReleaseNotes.md
+++ b/ReleaseNotes.md
@@ -1,3 +1,37 @@
+# Release_2021.03.5
+(Changes relative to Release_2021.03.4)
+
+## Acknowledgements
+Jason Biggs, Brian Kelley, Lewis J. Martin, Dan Nealschneider, Ricardo
+Rodriguez-Schmidt, David Slochower, Paolo Tosco, Maciej Wójcikowski
+
+## Bug Fixes:
+  - cannot pass drawOptions to MolsToGridImage when using notebook
+ (github #3101 from slochower)
+  - call to AvalonTools::set2DCoords results in an assert violation
+ (github #4330 from jasondbiggs)
+  - MolBlock writer gives non-stereo double bonds "unspecified" parity
+ (github #4345 from d-b-w)
+  - Specified trans stereo being ignored during conformation generation in macrocycles
+ (github #4346 from greglandrum)
+  - Two MinGW build fixes and one MSVC build fix
+ (github #4347 from ptosco)
+  - Fixes RDK_BUILD_THREADSAFE_SSS=OFF build
+ (github #4349 from ptosco)
+  - Three more Windows build fixes
+ (github #4356 from ptosco)
+  - Specified grid spacing for ShapeTanimotoDistance is ignored.
+ (github #4364 from greglandrum)
+  - Need implicit H cleanup after rdMolEnumerator.Enumerate()
+ (github #4381 from greglandrum)
+  - rdMolEnumerator.Enumerate fails on variable attachment points with queries
+ (github #4382 from greglandrum)
+  - RDKit reaction produces wrong double bond stereochemistry
+ (github #4410 from mwojcikowski)
+  - v2000 SGroups do not generate an "index" property
+ (github #4434 from ricrogz)
+
+
 # Release_2021.03.4
 (Changes relative to Release_2021.03.3)
 
@@ -5,8 +39,6 @@
 Brian Kelley, Rasmus Lundsgaard, Dan Nealschneider, Ricardo Rodriguez-Schmidt,
 Matt Swain, Paolo Tosco, Kazuya Ujihara, Alain Vaucher, 'jungb-basf' 
 
-
-
 ## Bug Fixes:
   - EnumerateStereoisomers fail with STEREOANY bonds from molblock
  (github #3759 from TermeHansen)
@@ -38,8 +70,6 @@ Matt Swain, Paolo Tosco, Kazuya Ujihara, Alain Vaucher, 'jungb-basf'
  (github #4311 from greglandrum)
 
 
-
-
 # Release_2021.03.3
 (Changes relative to Release_2021.03.2)