rdkit/Code/GraphMol/WedgeBonds.cpp

//
//  Copyright (C) 2023 Greg Landrum and other RDKit contributors
//
//   @@ All Rights Reserved @@
//  This file is part of the RDKit.
//  The contents are covered by the terms of the BSD license
//  which is included in the file license.txt, found at the root
//  of the RDKit source tree.
//
#include <GraphMol/RDKitBase.h>
#include <GraphMol/Atropisomers.h>
#include <RDGeneral/types.h>
#include <sstream>
#include <set>
#include <algorithm>
#include <RDGeneral/utils.h>
#include <RDGeneral/Invariant.h>
#include <RDGeneral/RDLog.h>

#include <boost/dynamic_bitset.hpp>
#include <Geometry/point.h>
#include "Chirality.h"

#include <cstdlib>

namespace RDKit {

namespace Chirality {

const BondWedgingParameters defaultWedgingParams;

namespace {
std::tuple<unsigned int, unsigned int, unsigned int> getDoubleBondPresence(
    const ROMol &mol, const Atom &atom) {
  unsigned int hasDouble = 0;
  unsigned int hasKnownDouble = 0;
  unsigned int hasAnyDouble = 0;
  for (const auto bond : mol.atomBonds(&atom)) {
    if (bond->getBondType() == Bond::BondType::DOUBLE) {
      ++hasDouble;
      if (bond->getStereo() == Bond::BondStereo::STEREOANY) {
        ++hasAnyDouble;
      } else if (bond->getStereo() > Bond::BondStereo::STEREOANY) {
        ++hasKnownDouble;
      }
    }
  }
  return std::make_tuple(hasDouble, hasKnownDouble, hasAnyDouble);
}
}  // namespace

namespace detail {

std::pair<bool, INT_VECT> countChiralNbrs(const ROMol &mol, int noNbrs) {
  INT_VECT nChiralNbrs(mol.getNumAtoms(), noNbrs);

  // start by looking for bonds that are already wedged
  for (const auto bond : mol.bonds()) {
    if (bond->getBondDir() == Bond::BEGINWEDGE ||
        bond->getBondDir() == Bond::BEGINDASH ||
        bond->getBondDir() == Bond::UNKNOWN) {
      if (bond->getBeginAtom()->getChiralTag() == Atom::CHI_TETRAHEDRAL_CW ||
          bond->getBeginAtom()->getChiralTag() == Atom::CHI_TETRAHEDRAL_CCW) {
        nChiralNbrs[bond->getBeginAtomIdx()] = noNbrs + 1;
      } else if (bond->getEndAtom()->getChiralTag() ==
                     Atom::CHI_TETRAHEDRAL_CW ||
                 bond->getEndAtom()->getChiralTag() ==
                     Atom::CHI_TETRAHEDRAL_CCW) {
        nChiralNbrs[bond->getEndAtomIdx()] = noNbrs + 1;
      }
    }
  }

  // now rank atoms by the number of chiral neighbors or Hs they have:
  bool chiNbrs = false;
  for (const auto at : mol.atoms()) {
    if (nChiralNbrs[at->getIdx()] > noNbrs) {
      // std::cerr << " SKIPPING1: " << at->getIdx() << std::endl;
      continue;
    }
    auto type = at->getChiralTag();
    if (type != Atom::CHI_TETRAHEDRAL_CW && type != Atom::CHI_TETRAHEDRAL_CCW) {
      continue;
    }
    nChiralNbrs[at->getIdx()] = 0;
    chiNbrs = true;
    for (const auto nat : mol.atomNeighbors(at)) {
      if (nat->getAtomicNum() == 1) {
        // special case: it's an H... we weight these especially high:
        nChiralNbrs[at->getIdx()] -= 10;
        continue;
      }
      type = nat->getChiralTag();
      if (type != Atom::CHI_TETRAHEDRAL_CW &&
          type != Atom::CHI_TETRAHEDRAL_CCW) {
        continue;
      }
      nChiralNbrs[at->getIdx()] -= 1;
    }
  }
  return std::make_pair(chiNbrs, nChiralNbrs);
}

//
// Determine bond wedge state
///
Bond::BondDir determineBondWedgeState(const Bond *bond,
                                      unsigned int fromAtomIdx,
                                      const Conformer *conf) {
  PRECONDITION(bond, "no bond");
  PRECONDITION(bond->getBondType() == Bond::SINGLE,
               "bad bond order for wedging");
  const auto mol = &(bond->getOwningMol());
  PRECONDITION(mol, "no mol");

  auto res = bond->getBondDir();
  if (!conf) {
    return res;
  }

  Atom *atom;
  Atom *bondAtom;
  if (bond->getBeginAtom()->getIdx() == fromAtomIdx) {
    atom = bond->getBeginAtom();
    bondAtom = bond->getEndAtom();
  } else {
    atom = bond->getEndAtom();
    bondAtom = bond->getBeginAtom();
  }

  auto chiralType = atom->getChiralTag();
  TEST_ASSERT(chiralType == Atom::CHI_TETRAHEDRAL_CW ||
              chiralType == Atom::CHI_TETRAHEDRAL_CCW);

  // if we got this far, we really need to think about it:
  std::list<int> neighborBondIndices;
  std::list<double> neighborBondAngles;
  auto centerLoc = conf->getAtomPos(atom->getIdx());
  auto tmpPt = conf->getAtomPos(bondAtom->getIdx());
  centerLoc.z = 0.0;
  tmpPt.z = 0.0;

  RDGeom::Point3D refVect;
  try {
    refVect = centerLoc.directionVector(tmpPt);
  } catch (const std::runtime_error &) {
    // we have a problem with the reference bond;
    // it's probably that the center and the tmp atom overlap
    return res;
  }

  neighborBondIndices.push_back(bond->getIdx());
  neighborBondAngles.push_back(0.0);
  for (const auto nbrBond : mol->atomBonds(atom)) {
    const auto otherAtom = nbrBond->getOtherAtom(atom);
    if (nbrBond != bond) {
      tmpPt = conf->getAtomPos(otherAtom->getIdx());
      tmpPt.z = 0.0;
      RDGeom::Point3D tmpVect;
      try {
        tmpVect = centerLoc.directionVector(tmpPt);
      } catch (const std::runtime_error &) {
        // we have a problem with the tmp bond;
        // it's probably that the atoms overlap
        return res;
      }
      auto angle = refVect.signedAngleTo(tmpVect);
      if (angle < 0.0) {
        angle += 2. * M_PI;
      }
      auto nbrIt = neighborBondIndices.begin();
      auto angleIt = neighborBondAngles.begin();
      // find the location of this neighbor in our angle-sorted list
      // of neighbors:
      while (angleIt != neighborBondAngles.end() && angle > (*angleIt)) {
        ++angleIt;
        ++nbrIt;
      }
      neighborBondAngles.insert(angleIt, angle);
      neighborBondIndices.insert(nbrIt, nbrBond->getIdx());
    }
  }

  // at this point, neighborBondIndices contains a list of bond
  // indices from the central atom.  They are arranged starting
  // at the reference bond in CCW order (based on the current
  // depiction).

  // if we already have one bond with direction set, then we can use it to
  // decide what the direction of this one is

  // we're starting from scratch... do the work!
  int nSwaps = atom->getPerturbationOrder(neighborBondIndices);

  // in the case of three-coordinated atoms we may have to worry about
  // the location of the implicit hydrogen - Issue 209
  // Check if we have one of these situation
  //
  //      0        1 0 2
  //      *         \*/
  //  1 - C - 2      C
  //
  // here the hydrogen will be between 1 and 2 and we need to add an
  // additional swap
  if (neighborBondAngles.size() == 3) {
    // three coordinated
    auto angleIt = neighborBondAngles.begin();
    ++angleIt;  // the first is the 0 (or reference bond - we will ignore
                // that
    double angle1 = (*angleIt);
    ++angleIt;
    double angle2 = (*angleIt);
    constexpr double angleTol =
        M_PI * 1.9 / 180.;  // just under 2 degrees tolerance, which is what we
                            // use when perceiving T-shaped geometries
    if (angle2 - angle1 >= (M_PI - angleTol)) {
      // we have the above situation
      nSwaps++;
    }
  }

#ifdef VERBOSE_STEREOCHEM
  BOOST_LOG(rdDebugLog) << "--------- " << nSwaps << std::endl;
  std::copy(neighborBondIndices.begin(), neighborBondIndices.end(),
            std::ostream_iterator<int>(BOOST_LOG(rdDebugLog), " "));
  BOOST_LOG(rdDebugLog) << std::endl;
  std::copy(neighborBondAngles.begin(), neighborBondAngles.end(),
            std::ostream_iterator<double>(BOOST_LOG(rdDebugLog), " "));
  BOOST_LOG(rdDebugLog) << std::endl;
#endif
  if (chiralType == Atom::CHI_TETRAHEDRAL_CCW) {
    if (nSwaps % 2 == 1) {
      res = Bond::BEGINDASH;
    } else {
      res = Bond::BEGINWEDGE;
    }
  } else {
    if (nSwaps % 2 == 1) {
      res = Bond::BEGINWEDGE;
    } else {
      res = Bond::BEGINDASH;
    }
  }

  return res;
}
Bond::BondDir determineBondWedgeState(
    const Bond *bond,
    const std::map<int, std::unique_ptr<RDKit::Chirality::WedgeInfoBase>>
        &wedgeBonds,
    const Conformer *conf) {
  PRECONDITION(bond, "no bond");
  int bid = bond->getIdx();
  auto wbi = wedgeBonds.find(bid);
  if (wbi == wedgeBonds.end()) {
    return bond->getBondDir();
  }

  if (wbi->second->getType() ==
      Chirality::WedgeInfoType::WedgeInfoTypeAtropisomer) {
    return wbi->second->getDir();
  } else {
    return determineBondWedgeState(bond, wbi->second->getIdx(), conf);
  }
}

// Logic for two wedges at one atom (based on IUPAC stuff)
// - at least four neighbors
// - neighboring bonds get wedged
// - same rules for picking which one for first
// - not ring bonds (?)

// picks a bond for atom that we will wedge when we write the mol file
// returns idx of that bond.
int pickBondToWedge(
    const Atom *atom, const ROMol &mol, const INT_VECT &nChiralNbrs,
    const std::map<int, std::unique_ptr<Chirality::WedgeInfoBase>> &wedgeBonds,
    int noNbrs) {
  // here is what we are going to do
  // - at each chiral center look for a bond that is begins at the atom and
  //   is not yet picked to be wedged for a different chiral center, preferring
  //   bonds to Hs
  // - if we do not find a bond that begins at the chiral center - we will take
  //   the first bond that is not yet picked by any other chiral centers
  // we use the orders calculated above to determine which order to do the
  // wedging

  // we need ring information; make sure findSSSR has been called before
  // if not call now
  if (!mol.getRingInfo()->isSssrOrBetter()) {
    MolOps::findSSSR(mol);
  }

  std::vector<std::pair<int, int>> nbrScores;
  for (const auto bond : mol.atomBonds(atom)) {
    // can only wedge single bonds:
    if (bond->getBondType() != Bond::SINGLE) {
      continue;
    }

    int bid = bond->getIdx();
    if (wedgeBonds.find(bid) == wedgeBonds.end()) {
      // very strong preference for Hs:
      auto *oatom = bond->getOtherAtom(atom);
      if (oatom->getAtomicNum() == 1) {
        nbrScores.emplace_back(-1000000,
                               bid);  // lower than anything else can be
        continue;
      }
      // prefer lower atomic numbers with lower degrees and no specified
      // chirality:
      int nbrScore = oatom->getAtomicNum() + 100 * oatom->getDegree() +
                     1000 * ((oatom->getChiralTag() != Atom::CHI_UNSPECIFIED));
      // prefer neighbors that are nonchiral or have as few chiral neighbors
      // as possible:
      int oIdx = oatom->getIdx();
      if (nChiralNbrs[oIdx] < noNbrs) {
        // the counts are negative, so we have to subtract them off
        nbrScore -= 100000 * nChiralNbrs[oIdx];
      }
      // prefer bonds to non-ring atoms:
      nbrScore += 10000 * mol.getRingInfo()->numAtomRings(oIdx);
      // prefer non-ring bonds;
      nbrScore += 20000 * mol.getRingInfo()->numBondRings(bid);
      // prefer bonds to atoms which don't have a double bond from them
      auto [hasDoubleBond, hasKnownDoubleBond, hasAnyDoubleBond] =
          getDoubleBondPresence(mol, *oatom);
      nbrScore += 11000 * hasDoubleBond;
      nbrScore += 12000 * hasKnownDoubleBond;
      nbrScore += 23000 * hasAnyDoubleBond;

      // if at all possible, do not go to marked attachment points
      // since they may well be removed when we write a mol block
      if (oatom->hasProp(common_properties::_fromAttachPoint)) {
        nbrScore += 500000;
      }
      // std::cerr << "    nrbScore: " << idx << " - " << oIdx << " : "
      //           << nbrScore << " nChiralNbrs: " << nChiralNbrs[oIdx]
      //           << std::endl;
      nbrScores.emplace_back(nbrScore, bid);
    }
  }
  // There's still one situation where this whole thing can fail: an unlucky
  // situation where all neighbors of all neighbors of an atom are chiral
  // and that atom ends up being the last one picked for stereochem
  // assignment. This also happens in cases where the chiral atom doesn't
  // have all of its neighbors (like when working with partially sanitized
  // fragments)
  //
  // We'll bail here by returning -1
  if (nbrScores.empty()) {
    return -1;
  }
  auto minPr = std::min_element(nbrScores.begin(), nbrScores.end());
  return minPr->second;
}

}  // namespace detail

// returns map of bondIdx -> bond begin atom for those bonds that
// need wedging.

std::map<int, std::unique_ptr<Chirality::WedgeInfoBase>> pickBondsToWedge(
    const ROMol &mol, const BondWedgingParameters *params) {
  const Conformer *conf = nullptr;
  if (mol.getNumConformers()) {
    conf = &mol.getConformer();
  }

  return pickBondsToWedge(mol, params, conf);
}

std::map<int, std::unique_ptr<Chirality::WedgeInfoBase>> pickBondsToWedge(
    const ROMol &mol, const BondWedgingParameters *params,
    const Conformer *conf) {
  if (!params) {
    params = &defaultWedgingParams;
  }
  std::vector<unsigned int> indices(mol.getNumAtoms());
  std::iota(indices.begin(), indices.end(), 0);
  static int noNbrs = 100;
  auto [chiNbrs, nChiralNbrs] = detail::countChiralNbrs(mol, noNbrs);
  if (chiNbrs) {
    std::sort(indices.begin(), indices.end(),
              [&nChiralNbrs = nChiralNbrs](auto i1, auto i2) {
                return nChiralNbrs[i1] < nChiralNbrs[i2];
              });
  }
  std::map<int, std::unique_ptr<Chirality::WedgeInfoBase>> wedgeInfo;
  for (auto idx : indices) {
    if (nChiralNbrs[idx] > noNbrs) {
      // std::cerr << " SKIPPING2: " << idx << std::endl;
      continue;  // already have a wedged bond here
    }
    auto atom = mol.getAtomWithIdx(idx);
    auto type = atom->getChiralTag();
    // the indices are ordered such that all chiral atoms come first. If
    // this has no chiral flag, we can stop the whole loop:
    if (type != Atom::CHI_TETRAHEDRAL_CW && type != Atom::CHI_TETRAHEDRAL_CCW) {
      break;
    }
    auto bnd1 =
        detail::pickBondToWedge(atom, mol, nChiralNbrs, wedgeInfo, noNbrs);
    if (bnd1 >= 0) {
      auto wi = std::unique_ptr<RDKit::Chirality::WedgeInfoChiral>(
          new RDKit::Chirality::WedgeInfoChiral(idx));
      wedgeInfo[bnd1] = std::move(wi);
    }
  }
  RDKit::Atropisomers::wedgeBondsFromAtropisomers(mol, conf, wedgeInfo);

  return wedgeInfo;
}

namespace {
// conditions here:
// 1. only degree four atoms (IUPAC)
// 2. no ring bonds (IUPAC)
// 3. not to chiral atoms (general IUPAC wedging rule)
void addSecondWedgeAroundAtom(ROMol &mol, Bond *refBond,
                              const Conformer *conf) {
  PRECONDITION(refBond, "no reference bond provided");
  PRECONDITION(conf, "no conformer provided");
  auto atom = refBond->getBeginAtom();
  // we only do degree four atoms (per IUPAC recommendation)
  if (atom->getDegree() < 4) {
    return;
  }
  auto aloc = conf->getAtomPos(atom->getIdx());
  aloc.z = 0.0;
  auto refVect = conf->getAtomPos(refBond->getEndAtomIdx());
  refVect.z = 0.0;
  refVect = aloc.directionVector(refVect);
  double minAngle = 10000.0;
  unsigned int bestDegree = 100;
  Bond *bondToWedge = nullptr;
  for (auto bond : mol.atomBonds(atom)) {
    if (bond == refBond || bond->getBondType() != Bond::BondType::SINGLE ||
        bond->getBondDir() != Bond::BondDir::NONE ||
        bond->getOtherAtom(atom)->getChiralTag() !=
            Atom::ChiralType::CHI_UNSPECIFIED ||
        mol.getRingInfo()->numBondRings(bond->getIdx())) {
      continue;
    }

    // FIX: There's more checking required here

    auto bVect = conf->getAtomPos(bond->getOtherAtomIdx(atom->getIdx()));
    bVect.z = 0.0;
    bVect = aloc.directionVector(bVect);
    auto angle = refVect.angleTo(bVect);
    if ((angle - minAngle) < 5 * M_PI / 180 &&
        bond->getOtherAtom(atom)->getDegree() <= bestDegree) {
      bondToWedge = bond;
      minAngle = angle;
      bestDegree = bond->getOtherAtom(atom)->getDegree();
    }
  }
  // if we got a bond and the angle is < 120 degrees (quasi-arbitrary)
  if (bondToWedge && minAngle < 2 * M_PI / 3) {
    bondToWedge->setBondDir(refBond->getBondDir() == Bond::BondDir::BEGINDASH
                                ? Bond::BondDir::BEGINWEDGE
                                : Bond::BondDir::BEGINDASH);
    if (bondToWedge->getBeginAtomIdx() != atom->getIdx()) {
      bondToWedge->setEndAtomIdx(bondToWedge->getBeginAtomIdx());
      bondToWedge->setBeginAtomIdx(atom->getIdx());
    }
  }
}
}  // namespace

void wedgeMolBonds(ROMol &mol, const Conformer *conf,
                   const BondWedgingParameters *params) {
  PRECONDITION(conf || mol.getNumConformers(), "no conformer available");
  if (!conf) {
    conf = &mol.getConformer();
  }
  if (!params) {
    params = &defaultWedgingParams;
  }
  // we need ring info
  if (!mol.getRingInfo() || !mol.getRingInfo()->isSssrOrBetter()) {
    MolOps::findSSSR(mol);
  }

  auto wedgeBonds = Chirality::pickBondsToWedge(mol, params, conf);

  // loop over the bonds we need to wedge:
  for (const auto &[wbi, wedgeInfo] : wedgeBonds) {
    if (wedgeInfo->getType() ==
        Chirality::WedgeInfoType::WedgeInfoTypeAtropisomer) {
      mol.getBondWithIdx(wbi)->setBondDir(wedgeInfo->getDir());
    } else {  // chiral atom needs wedging
      auto bond = mol.getBondWithIdx(wbi);
      auto dir =
          detail::determineBondWedgeState(bond, wedgeInfo->getIdx(), conf);
      if (dir == Bond::BEGINWEDGE || dir == Bond::BEGINDASH) {
        bond->setBondDir(dir);

        // it is possible that this
        // wedging was determined by a chiral atom at the end of the
        // bond (instead of at the beginning). In this case we need to
        // reverse the begin and end atoms for the bond
        if (static_cast<unsigned int>(wedgeInfo->getIdx()) !=
            bond->getBeginAtomIdx()) {
          auto tmp = bond->getBeginAtomIdx();
          bond->setBeginAtomIdx(bond->getEndAtomIdx());
          bond->setEndAtomIdx(tmp);
        }
      }
    }
  }
  if (params->wedgeTwoBondsIfPossible) {
    // This should probably check whether the existing wedge
    // is in agreement with the chiral tag on the atom.

    for (const auto atom : mol.atoms()) {
      if (atom->getChiralTag() != Atom::CHI_TETRAHEDRAL_CW &&
          atom->getChiralTag() != Atom::CHI_TETRAHEDRAL_CCW) {
        continue;
      }
      unsigned numWedged = 0;
      Bond *wedgedBond = nullptr;
      for (const auto bond : mol.atomBonds(atom)) {
        if (bond->getBeginAtom() == atom &&
            bond->getBondType() == Bond::SINGLE &&
            (bond->getBondDir() == Bond::BEGINWEDGE ||
             bond->getBondDir() == Bond::BEGINDASH)) {
          ++numWedged;
          wedgedBond = bond;
        }
      }
      if (numWedged == 1) {
        addSecondWedgeAroundAtom(mol, wedgedBond, conf);
      }
    }
  }
}

void wedgeBond(Bond *bond, unsigned int fromAtomIdx, const Conformer *conf) {
  PRECONDITION(bond, "no bond");
  PRECONDITION(conf, "no conformer");
  PRECONDITION(&conf->getOwningMol() == &bond->getOwningMol(),
               "bond and conformer do not belong to same molecule");
  if (bond->getBondType() != Bond::SINGLE) {
    return;
  }
  Bond::BondDir dir = detail::determineBondWedgeState(bond, fromAtomIdx, conf);
  if (dir == Bond::BEGINWEDGE || dir == Bond::BEGINDASH) {
    bond->setBondDir(dir);
  }
}

bool wedgingHasChirality(const ROMol &mol, const Bond *b) {
  // see if this wedge should have wedging.  It can if the begin atom
  // has chirality or the begin atom is the part of an atropisomer bond

  Atom *atom = b->getBeginAtom();
  if (atom->getChiralTag() != Atom::CHI_UNSPECIFIED) {
    return true;
  }

  // see if this is part of an atropisomer bond
  for (const auto bond2 : mol.atomBonds(atom)) {
    if (bond2->getBondType() == Bond::BondType::SINGLE) {
      if (bond2 == b) {
        continue;  // a bond is NOT its own neighbor
      }
      if (bond2->getStereo() == Bond::STEREOATROPCCW ||
          bond2->getStereo() == Bond::STEREOATROPCW) {
        return true;
      }
    }
  }

  return false;
}

void reapplyMolBlockWedging(ROMol &mol, bool allBondTypes,
                            bool verify) {
  MolOps::clearDirFlags(mol, true);
  for (auto b : mol.bonds()) {
    int explicit_unknown_stereo = -1;
    if (b->getPropIfPresent<int>(common_properties::_UnknownStereo,
                                 explicit_unknown_stereo) &&
        explicit_unknown_stereo) {
      b->setBondDir(Bond::UNKNOWN);
    }

    // if the bond is not a double bond, and it is not connected to an
    // atropisomer bond AND if the start atom  is not chiral, we will skip it -
    // it should not have a wedge or dash

    if (verify &&
        (!canHaveDirection(*b) || !wedgingHasChirality(mol, b))) {
      continue;
    }

    int bond_dir = -1;
    if (b->getPropIfPresent<int>(common_properties::_MolFileBondStereo,
                                 bond_dir)) {
      if (allBondTypes || canHaveDirection(*b)) {
        if (bond_dir == 1) {
          b->setBondDir(Bond::BEGINWEDGE);
        } else if (bond_dir == 6) {
          b->setBondDir(Bond::BEGINDASH);
        }
      }
      if (b->getBondType() == Bond::DOUBLE) {
        if (bond_dir == 0 && b->getStereo() == Bond::STEREOANY) {
          b->setBondDir(Bond::NONE);
          b->setStereo(Bond::STEREONONE);
        } else if (bond_dir == 3) {
          b->setBondDir(Bond::EITHERDOUBLE);
          b->setStereo(Bond::STEREOANY);
        }
      }
    }
    int cfg = -1;
    b->getPropIfPresent<int>(common_properties::_MolFileBondCfg, cfg);
    switch (cfg) {
      case 1:
        if (allBondTypes || canHaveDirection(*b)) {
          b->setBondDir(Bond::BEGINWEDGE);
        }
        break;
      case 2:
        if (canHaveDirection(*b)) {
          b->setBondDir(Bond::UNKNOWN);
        } else if (b->getBondType() == Bond::DOUBLE) {
          b->setBondDir(Bond::EITHERDOUBLE);
          b->setStereo(Bond::STEREOANY);
        }
        break;
      case 3:
        if (allBondTypes || canHaveDirection(*b)) {
          b->setBondDir(Bond::BEGINDASH);
        }
        break;
      case 0:
      case -1:
        if (bond_dir == -1 && b->getBondType() == Bond::DOUBLE &&
            b->getStereo() == Bond::STEREOANY) {
          b->setBondDir(Bond::NONE);
          b->setStereo(Bond::STEREONONE);
        }
    }
  }
}

void clearMolBlockWedgingInfo(ROMol &mol) {
  for (auto b : mol.bonds()) {
    b->clearProp(common_properties::_MolFileBondStereo);
    b->clearProp(common_properties::_MolFileBondCfg);
  }
}

void invertMolBlockWedgingInfo(ROMol &mol) {
  for (auto b : mol.bonds()) {
    int bond_dir = -1;
    if (b->getPropIfPresent<int>(common_properties::_MolFileBondStereo,
                                 bond_dir)) {
      if (bond_dir == 1) {
        b->setProp<int>(common_properties::_MolFileBondStereo, 6);
      } else if (bond_dir == 6) {
        b->setProp<int>(common_properties::_MolFileBondStereo, 1);
      }
    }
    int cfg = -1;
    if (b->getPropIfPresent<int>(common_properties::_MolFileBondCfg, cfg)) {
      if (cfg == 1) {
        b->setProp<int>(common_properties::_MolFileBondCfg, 3);
      } else if (cfg == 3) {
        b->setProp<int>(common_properties::_MolFileBondCfg, 1);
      }
    }
  }
}

}  // namespace Chirality
}  // namespace RDKit