rdkit/External/INCHI-API/test.cpp

#include <iostream>
#include <fstream>
#include <boost/algorithm/string.hpp>
#include <boost/algorithm/string/trim.hpp>
#include <boost/lexical_cast.hpp>
#include <boost/foreach.hpp>

#include <RDGeneral/Invariant.h>
#include <RDGeneral/RDLog.h>
#include <RDGeneral/utils.h>
#include <RDGeneral/StreamOps.h>

#include <GraphMol/RDKitBase.h>
#include <GraphMol/MolPickler.h>
#include <GraphMol/SmilesParse/SmilesParse.h>
#include <GraphMol/SmilesParse/SmilesWrite.h>
#include <GraphMol/FileParsers/FileParsers.h>
#include <GraphMol/FileParsers/MolSupplier.h>

#include <GraphMol/Descriptors/MolDescriptors.h>
#include <GraphMol/Descriptors/Crippen.h>

#include <DataStructs/BitVects.h>
#include <DataStructs/BitOps.h>
#include "inchi.h"

using namespace RDKit;

#ifdef RDK_TEST_MULTITHREADED
namespace {
void runblock(const std::vector<ROMol *> &mols, unsigned int count,
              unsigned int idx, std::vector<std::string> &inchis,
              const std::vector<std::string> &keys) {
  for (unsigned int j = 0; j < 200; j++) {
    for (unsigned int i = 0; i < mols.size(); ++i) {
      if (i % count != idx) continue;
      ROMol *mol = mols[i];
      ExtraInchiReturnValues tmp;
      std::string inchi = MolToInchi(*mol, tmp);
      TEST_ASSERT(inchi == inchis[i]);
      std::string key = InchiToInchiKey(inchi);
      TEST_ASSERT(key == keys[i]);
      std::string key2 = MolToInchiKey(*mol);
      TEST_ASSERT(key2 == keys[i]);
      ROMol *mol2 = InchiToMol(inchi, tmp);
      TEST_ASSERT(mol2);
      ExtraInchiReturnValues tmp2;
      std::string inchi2 = MolToInchi(*mol2, tmp2);
      TEST_ASSERT(inchi == inchi2);
      delete mol2;
    }
  }
};
}

#include <thread>
#include <future>
void testMultiThread() {
  BOOST_LOG(rdErrorLog) << "-------------------------------------" << std::endl;
  BOOST_LOG(rdErrorLog) << "    Test multithreading" << std::endl;

  std::string fName = getenv("RDBASE");
  fName += "/Data/NCI/first_200.props.sdf";
  SDMolSupplier suppl(fName);
  std::cerr << "reading molecules" << std::endl;
  std::vector<ROMol *> mols;
  while (!suppl.atEnd() && mols.size() < 100) {
    ROMol *mol = 0;
    try {
      mol = suppl.next();
    } catch (...) {
      continue;
    }
    if (!mol) continue;
    mols.push_back(mol);
  }
  std::cerr << "generating reference data" << std::endl;
  std::vector<std::string> inchis;
  std::vector<std::string> keys;
  BOOST_FOREACH (const ROMol *mol, mols) {
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*mol, tmp);
    std::string key = InchiToInchiKey(inchi);
    inchis.push_back(inchi);
    keys.push_back(key);
  }

  std::vector<std::future<void>> tg;
  std::cerr << "processing" << std::endl;
  unsigned int count = 4;
  for (unsigned int i = 0; i < count; ++i) {
    std::cerr << " launch :" << i << std::endl;
    std::cerr.flush();
    tg.emplace_back(std::async(std::launch::async, runblock, std::ref(mols),
                               count, i, std::ref(inchis), std::ref(keys)));
  }
  for (auto &fut : tg) {
    fut.get();
  }

  for (unsigned int i = 0; i < mols.size(); ++i) delete mols[i];

  BOOST_LOG(rdErrorLog) << "  done" << std::endl;
}
#else
void testMultiThread() {
  {}
}
#endif

void testGithubIssue3() {
  BOOST_LOG(rdErrorLog) << "-------------------------------------" << std::endl;
  BOOST_LOG(rdInfoLog)
      << "testing github issue 3: bad inchis when mol has no stereoinfo"
      << std::endl;
  {
    std::string fName = getenv("RDBASE");
    fName += "/External/INCHI-API/test_data/github3.mol";
    ROMol *m = static_cast<ROMol *>(MolFileToMol(fName));
    TEST_ASSERT(m);
    std::string smi = MolToSmiles(*m, true);
    TEST_ASSERT(smi == "CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO");

    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    TEST_ASSERT(inchi ==
                "InChI=1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/"
                "h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1");

    // blow out the stereo information with a copy:
    RWMol *m2 = new RWMol(*m);
    m2->clearComputedProps();
    MolOps::sanitizeMol(*m2);

    inchi = MolToInchi(*m2, tmp);
    TEST_ASSERT(inchi ==
                "InChI=1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/"
                "h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1");

    delete m;
    delete m2;
  }
  BOOST_LOG(rdInfoLog) << "done" << std::endl;
}

void testGithubIssue8() {
  BOOST_LOG(rdErrorLog) << "-------------------------------------" << std::endl;
  BOOST_LOG(rdInfoLog) << "testing a consequence of the fix for github issue "
                          "8: bad mols from some inchis"
                       << std::endl;
  {
    std::string fName = getenv("RDBASE");
    fName += "/External/INCHI-API/test_data/github8_extra.mol";
    ROMol *m = static_cast<ROMol *>(MolFileToMol(fName, true, false));
    TEST_ASSERT(m);

    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    TEST_ASSERT(inchi ==
                "InChI=1S/C20H13IN2O3/"
                "c21-15-8-14-18(9-16(15)23)26-17-7-10(22)5-6-13(17)19(14)11-3-"
                "1-2-4-12(11)20(24)25/h1-9,23H,22H2,(H,24,25)/b23-16+/i21-2");

    ExtraInchiReturnValues tmp2;
    ROMol *m2 = InchiToMol(inchi, tmp2);
    TEST_ASSERT(m2);
    std::string smi = MolToSmiles(*m2, true);
    TEST_ASSERT(smi == "[H]/N=c1\\cc2oc3cc(N)ccc3c(-c3ccccc3C(=O)O)c-2cc1[125I]");

    inchi = MolToInchi(*m2, tmp2);
    TEST_ASSERT(inchi == 
                "InChI=1S/C20H13IN2O3/"
                "c21-15-8-14-18(9-16(15)23)26-17-7-10(22)5-6-13(17)19(14)11-3-"
                "1-2-4-12(11)20(24)25/h1-9,23H,22H2,(H,24,25)/b23-16+/i21-2");
    delete m;
    delete m2;
  }
  BOOST_LOG(rdInfoLog) << "done" << std::endl;
}

void testGithubIssue40() {
  BOOST_LOG(rdErrorLog) << "-------------------------------------" << std::endl;
  BOOST_LOG(rdInfoLog) << "testing github issue 40: bad MWs from inchis"
                       << std::endl;
  {
    ExtraInchiReturnValues tmp;
    std::string inchi =
        "InChI=1S/C10H9N3O/c1-7-11-10(14)9(13-12-7)8-5-3-2-4-6-8/"
        "h2-6H,1H3,(H,11,12,14)";
    ROMol *m = InchiToMol(inchi, tmp);
    TEST_ASSERT(m);

    double mw = Descriptors::calcAMW(*m);
    TEST_ASSERT(feq(mw, 187.202));

    delete m;
  }
  BOOST_LOG(rdInfoLog) << "done" << std::endl;
}

void testGithubIssue67() {
  BOOST_LOG(rdErrorLog) << "-------------------------------------" << std::endl;
  BOOST_LOG(rdInfoLog) << "testing github issue 67: seg fault from inchi"
                       << std::endl;
  {
    ExtraInchiReturnValues tmp;
    std::string inchi =
        "InChI=1S/C18H17N3/"
        "c19-18(20)21-14-17-12-10-16(11-13-17)9-5-4-8-15-6-2-1-3-7-15/"
        "h1-3,6-13H,14H2,(H4,19,20,21)/b9-8+";
    ROMol *m = InchiToMol(inchi, tmp);
    TEST_ASSERT(m);
    TEST_ASSERT(m->getNumAtoms() == 21);

    delete m;
  }
  BOOST_LOG(rdInfoLog) << "done" << std::endl;
}

void testGithubIssue68() {
  BOOST_LOG(rdErrorLog) << "-------------------------------------" << std::endl;
  BOOST_LOG(rdInfoLog) << "testing github issue 68: hang while reading InChI"
                       << std::endl;
  {
    ExtraInchiReturnValues tmp;
    std::string inchi =
        "InChI=1S/C11H20NSSi2.Li/c1-14(2)8-9-15(3,4)12(14)10-11-6-5-7-13-11;/"
        "h6-7H,8-10H2,1-4H3;/q-1;+1";
    BOOST_LOG(rdInfoLog) << "  parse 1:" << std::endl;
    ROMol *m = InchiToMol(inchi, tmp);
    BOOST_LOG(rdInfoLog) << "  done" << std::endl;
    TEST_ASSERT(m);
    TEST_ASSERT(m->getNumAtoms() == 16);

    delete m;
  }
  {
    ExtraInchiReturnValues tmp;
    std::string inchi =
        "InChI=1S/C12H22NSSi2.Li/"
        "c1-15(2)10-11-16(3,4)13(15)8-7-12-6-5-9-14-12;/"
        "h6,9H,7-8,10-11H2,1-4H3;/q-1;+1";
    BOOST_LOG(rdInfoLog) << "  parse 2:" << std::endl;
    ROMol *m = InchiToMol(inchi, tmp);
    BOOST_LOG(rdInfoLog) << "  done" << std::endl;
    TEST_ASSERT(m);
    TEST_ASSERT(m->getNumAtoms() == 17);

    delete m;
  }
  BOOST_LOG(rdInfoLog) << "done" << std::endl;
}

void testGithubIssue296() {
  BOOST_LOG(rdErrorLog) << "-------------------------------------" << std::endl;
  BOOST_LOG(rdInfoLog)
      << "testing github issue 296: problems with chiral S and inchi"
      << std::endl;
  {
    std::string smiles = "C[S@@](=O)C(C)(C)C";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    TEST_ASSERT(inchi == "InChI=1S/C5H12OS/c1-5(2,3)7(4)6/h1-4H3/t7-/m1/s1");
    delete m;
  }

  {
    std::string fName = getenv("RDBASE");
    fName += "/External/INCHI-API/test_data/github296.mol";
    ROMol *m = static_cast<ROMol *>(MolFileToMol(fName));
    TEST_ASSERT(m);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    TEST_ASSERT(inchi == "InChI=1S/C5H12OS/c1-5(2,3)7(4)6/h1-4H3/t7-/m1/s1");
    delete m;
  }

  BOOST_LOG(rdInfoLog) << "done" << std::endl;
}

void testGithubIssue437() {
  BOOST_LOG(rdErrorLog) << "-------------------------------------" << std::endl;
  BOOST_LOG(rdInfoLog) << "testing github issue 437: problems with InChI and "
                          "ring stereochemistry"
                       << std::endl;

  // start with some general chirality checks
  {
    std::string smiles = "C[C@@H](F)Cl";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    std::string smi1 = MolToSmiles(*m, true);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    // std::cerr<<" result: "<<inchi<<std::endl;
    TEST_ASSERT(inchi == "InChI=1S/C2H4ClF/c1-2(3)4/h2H,1H3/t2-/m1/s1");

    delete m;
    m = InchiToMol(inchi, tmp);
    std::string smi2 = MolToSmiles(*m, true);
    // std::cerr<<" smi1: "<<smi1<<std::endl;
    // std::cerr<<" smi2: "<<smi2<<std::endl;
    TEST_ASSERT(smi1 == smi2);
  }
  {
    std::string smiles = "O=[S@](Cl)F";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    std::string smi1 = MolToSmiles(*m, true);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    // std::cerr<<" result: "<<inchi<<std::endl;
    TEST_ASSERT(inchi == "InChI=1S/ClFOS/c1-4(2)3/t4-/m1/s1");
    delete m;
    m = InchiToMol(inchi, tmp);
    std::string smi2 = MolToSmiles(*m, true);
    // std::cerr<<" smi1: "<<smi1<<std::endl;
    // std::cerr<<" smi2: "<<smi2<<std::endl;
    TEST_ASSERT(smi1 == smi2);
  }
  {
    std::string smiles = "C[C@@H](F)[C@H](C)[C@H](C)F";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    std::string smi1 = MolToSmiles(*m, true);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    // std::cerr<<" result: "<<inchi<<std::endl;
    TEST_ASSERT(inchi ==
                "InChI=1S/C6H12F2/c1-4(5(2)7)6(3)8/h4-6H,1-3H3/t4-,5+,6-");

    delete m;
    m = InchiToMol(inchi, tmp);
    std::string smi2 = MolToSmiles(*m, true);
    TEST_ASSERT(smi1 == smi2);
  }
  {
    std::string smiles = "C[C@@H](F)[C@H](C)[C@@H](C)F";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    std::string smi1 = MolToSmiles(*m, true);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    // std::cerr<<" result: "<<inchi<<std::endl;
    TEST_ASSERT(inchi ==
                "InChI=1S/C6H12F2/c1-4(5(2)7)6(3)8/h4-6H,1-3H3/t5-,6-/m1/s1");

    delete m;
    m = InchiToMol(inchi, tmp);
    std::string smi2 = MolToSmiles(*m, true);
    // std::cerr<<" smi1: "<<smi1<<std::endl;
    // std::cerr<<" smi2: "<<smi2<<std::endl;
    TEST_ASSERT(smi1 == smi2);
  }
  {
    std::string smiles = "C[C@H](F)[C@H](C)[C@H](C)F";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    std::string smi1 = MolToSmiles(*m, true);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    // std::cerr<<" result: "<<inchi<<std::endl;
    TEST_ASSERT(inchi ==
                "InChI=1S/C6H12F2/c1-4(5(2)7)6(3)8/h4-6H,1-3H3/t5-,6-/m0/s1");

    delete m;
    m = InchiToMol(inchi, tmp);
    std::string smi2 = MolToSmiles(*m, true);
    TEST_ASSERT(smi1 == smi2);
  }
  {
    std::string smiles = "C[C@H](F)[C@H](C)[C@@H](C)F";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    std::string smi1 = MolToSmiles(*m, true);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    // std::cerr<<" result: "<<inchi<<std::endl;
    TEST_ASSERT(inchi ==
                "InChI=1S/C6H12F2/c1-4(5(2)7)6(3)8/h4-6H,1-3H3/t4-,5-,6+");

    delete m;
    m = InchiToMol(inchi, tmp);
    std::string smi2 = MolToSmiles(*m, true);
    TEST_ASSERT(smi1 == smi2);
  }

  // now the rings
  {
    std::string smiles = "C[C@@H]1CC[C@@H](O)C[C@@H]1F";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    std::string smi1 = MolToSmiles(*m, true);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    // std::cerr<<" result: "<<inchi<<std::endl;
    TEST_ASSERT(inchi ==
                "InChI=1S/C7H13FO/c1-5-2-3-6(9)4-7(5)8/h5-7,9H,2-4H2,1H3/"
                "t5-,6-,7+/m1/s1");

    delete m;
    m = InchiToMol(inchi, tmp);
    std::string smi2 = MolToSmiles(*m, true);
    TEST_ASSERT(smi1 == smi2);
  }

  {
    std::string smiles = "C[C@@]1(F)CC[C@@](O)(F)CC1";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    std::string smi1 = MolToSmiles(*m, true);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    // std::cerr<<" result: "<<inchi<<std::endl;
    TEST_ASSERT(
        inchi ==
        "InChI=1S/C7H12F2O/c1-6(8)2-4-7(9,10)5-3-6/h10H,2-5H2,1H3/t6-,7+");
    delete m;
    m = InchiToMol(inchi, tmp);
    std::string smi2 = MolToSmiles(*m, true);
    TEST_ASSERT(smi1 == smi2);
  }
  {
    std::string smiles = "C[C@H]1CC[C@H](O)CC1";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    std::string smi1 = MolToSmiles(*m, true);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    // std::cerr<<" result: "<<inchi<<std::endl;
    TEST_ASSERT(inchi ==
                "InChI=1S/C7H14O/c1-6-2-4-7(8)5-3-6/h6-8H,2-5H2,1H3/t6-,7-");
    delete m;
    m = InchiToMol(inchi, tmp);
    std::string smi2 = MolToSmiles(*m, true);
    TEST_ASSERT(smi1 == smi2);
  }
  {
    std::string smiles = "C[C@H]1CC[C@](O)(F)CC1";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    std::string smi1 = MolToSmiles(*m, true);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    // std::cerr<<" result: "<<inchi<<std::endl;
    TEST_ASSERT(inchi ==
                "InChI=1S/C7H13FO/c1-6-2-4-7(8,9)5-3-6/h6,9H,2-5H2,1H3/t6-,7+");
    delete m;
    m = InchiToMol(inchi, tmp);
    std::string smi2 = MolToSmiles(*m, true);
    TEST_ASSERT(smi1 == smi2);
  }
  {
    // this was the original molecule in the bug report
    std::string smiles =
        "OC(=NCCc1ccccc1)[C@H]1CC[C@H](Cn2c(O)nc3ccccc3c2=O)CC1";
    ROMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    std::string smi1 = MolToSmiles(*m, true);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    TEST_ASSERT(inchi ==
                "InChI=1S/C24H27N3O3/"
                "c28-22(25-15-14-17-6-2-1-3-7-17)19-12-10-18(11-13-19)16-27-23("
                "29)20-8-4-5-9-21(20)26-24(27)30/"
                "h1-9,18-19H,10-16H2,(H,25,28)(H,26,30)/t18-,19-");
    delete m;
    m = InchiToMol(inchi, tmp);
    std::string smi2 = MolToSmiles(*m, true);
    TEST_ASSERT(smi1 == smi2);
  }
  BOOST_LOG(rdInfoLog) << "done" << std::endl;
}

void testGithubIssue562() {
  BOOST_LOG(rdErrorLog) << "-------------------------------------" << std::endl;
  BOOST_LOG(rdInfoLog)
      << "testing github issue 562: InChI radicals not properly converted"
      << std::endl;

  {
    std::string inchi = "InChI=1S/HO/h1H";
    ExtraInchiReturnValues tmp;
    ROMol *m = InchiToMol(inchi, tmp);
    TEST_ASSERT(m);
    TEST_ASSERT(m->getNumAtoms() == 1);
    TEST_ASSERT(m->getAtomWithIdx(0)->getNumRadicalElectrons() == 1);
    TEST_ASSERT(m->getAtomWithIdx(0)->getNumExplicitHs() == 1);
    TEST_ASSERT(m->getAtomWithIdx(0)->getNoImplicit() == true);

    std::string oinchi = MolToInchi(*m, tmp);

    TEST_ASSERT(oinchi == inchi);

    delete m;
  }
  BOOST_LOG(rdInfoLog) << "done" << std::endl;
}

void testGithubIssue614() {
  BOOST_LOG(rdErrorLog) << "-------------------------------------" << std::endl;
  BOOST_LOG(rdInfoLog) << "testing github issue 614: segfault from MolToInchi "
                          "when bad bond stereochem info is present"
                       << std::endl;

  {
    std::string smiles = "C/C=C/C";
    RWMol *m = SmilesToMol(smiles);
    TEST_ASSERT(m);
    m->removeAtom(3);
    ExtraInchiReturnValues tmp;
    std::string inchi = MolToInchi(*m, tmp);
    TEST_ASSERT(inchi == "InChI=1S/C3H6/c1-3-2/h3H,1H2,2H3");
    delete m;
  }
  BOOST_LOG(rdInfoLog) << "done" << std::endl;
}

void testGithubIssue1572() {
  BOOST_LOG(rdErrorLog) << "-------------------------------------" << std::endl;
  BOOST_LOG(rdInfoLog)
      << "testing github issue 1572: Incorrect conversion from InChI"
      << std::endl;

  {
    std::string inchi =
        "InChI=1S/C16H10N6O2/"
        "c23-21(15-9-17-11-5-1-3-7-13(11)19-15)22(24)16-10-18-12-6-2-4-8-14(12)"
        "20-16/h1-10H";
    ExtraInchiReturnValues tmp;
    RWMol *m = InchiToMol(inchi, tmp, false);
    TEST_ASSERT(m);
    TEST_ASSERT(m->getNumAtoms() == 24);
    m->updatePropertyCache(false);
    TEST_ASSERT(m->getAtomWithIdx(20)->getAtomicNum() == 7);
    TEST_ASSERT(m->getAtomWithIdx(21)->getAtomicNum() == 7);
    TEST_ASSERT(m->getAtomWithIdx(22)->getAtomicNum() == 8);
    TEST_ASSERT(m->getAtomWithIdx(23)->getAtomicNum() == 8);
    TEST_ASSERT(m->getAtomWithIdx(20)->getFormalCharge() == 0);
    TEST_ASSERT(m->getAtomWithIdx(21)->getFormalCharge() == 0);
    TEST_ASSERT(m->getAtomWithIdx(22)->getFormalCharge() == 0);
    TEST_ASSERT(m->getAtomWithIdx(23)->getFormalCharge() == 0);

    // and the molecule should be sanitizable:
    MolOps::sanitizeMol(*m);
    TEST_ASSERT(m->getAtomWithIdx(20)->getFormalCharge() == 1);
    TEST_ASSERT(m->getAtomWithIdx(21)->getFormalCharge() == 1);
    TEST_ASSERT(m->getAtomWithIdx(22)->getFormalCharge() == -1);
    TEST_ASSERT(m->getAtomWithIdx(23)->getFormalCharge() == -1);
    delete m;
  }
  BOOST_LOG(rdInfoLog) << "done" << std::endl;
}

//-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*
//
//-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*-*
int main() {
  RDLog::InitLogs();
#if 1
  testGithubIssue3();
  testGithubIssue8();
  testGithubIssue40();
  testGithubIssue67();
  testGithubIssue68();
  testGithubIssue296();
  testMultiThread();
  testGithubIssue437();
  testGithubIssue562();
  testGithubIssue614();
#endif
  testGithubIssue1572();
}