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## ESM C
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[ESM Cambrian](https://www.evolutionaryscale.ai/blog/esm-cambrian) is a parallel model family to our flagship ESM3 generative models. While ESM3 focuses on controllable generation of proteins for therapeutic and many other applications, ESM C focuses on creating representations of the underlying biology of proteins.
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ESM C comes with major performance benefits over ESM2. The 300M parameter ESM C delivers similar performance to ESM2 650M with dramatically reduced memory requirements and faster inference. The 600M parameter ESM C rivals the 3B parameter ESM2 and approaches the capabilities of the 15B model, delivering frontier performance with far greater efficiency. At the leading edge, the 6B parameter ESM C sets a new benchmark, outperforming all prior protein language models by a wide margin.
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ESM C comes with major performance benefits over ESM2. The 300M parameter ESM C delivers similar performance to ESM2 650M with dramatically reduced memory requirements and faster inference. The 600M parameter ESM C rivals the 3B parameter ESM2 and approaches the capabilities of the 15B model, delivering frontier performance with far greater efficiency. The 6B parameter ESM C sets a new benchmark, outperforming the best ESM2 models by a wide margin.
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ESM C models are available immediately for academic and commercial use under a new license structure designed to promote openness and enable scientists and builders. You can find our [open](www.evolutionaryscale.ai/policies/cambrian-open-license-agreement) and [non-commercial](www.evolutionaryscale.ai/policies/cambrian-non-commercial-license-agreement) license agreements here.
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