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# PPLM: A Corporative Language Model for Protein-Protein Interaction, Binding Affinity, and Interface Contact Prediction
# PPLM: A Paired Sequence Language Model for Protein-Protein Interaction Modeling
![PPLM Pipeline](Pipeline.png)
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**Version 1.0, 03/25/2025**
(Copyrighted by the Regents of the National University of Singapore, All rights reserved)
PPLM is a protein–protein language model that learns directly from paired sequences through a novel
PPLM is a protein–pair language model that learns directly from paired sequences through a novel
attention architecture, explicitly capturing inter-protein context. Building on PPLM, we developed
PPLM-PPI, PPLM-Affinity, and PPLM-Contact for predicting protein–protein interactions, estimating
binding affinity, and identifying interface residue contacts, respectively.